MTL - Pirate’s Brood Order - v3 Chapter 299 found unusual

In the rebirth, in order to prevent the tragedy of the previous life from happening, Bai Yu decided to rush to the [Tower of God] at any cost, and face everything together with his sister!

However, Bai Yu, who was bound by the system, mutated his bloodline, and transformed into a black-scaled python seems to be developing on a completely different path from his previous life…

- Description from novelbuddy

After her life ended, Nan Fei Yu was bonded to a Villain System. In order to complete the system’s tasks as soon as possible and reshape her body, she became a villain that everyone hated. Everyone wanted her to die! However, if the villain was delicate and soft, did it bring an alluring hallo?

- Description from Novelupdates

After his parents died, Alex Roth had a plan: become a wizard. Through hard work, he was accepted into the world’s greatest university of wizardry—but fate had another plan.

On his eighteenth, he is marked as one of his kingdom’s five Heroes, chosen to fight the land’s great enemy. But his brand is 'The Fool', worst of the marks.

Rather than die or serve the other Heroes like Fools in the past, he packs up his little sister, his childhood friend and her cerberus, then flees for the university in hope of refuge, magic and to unravel the truth about his land’s evil.

There’s one small problem: The Mark tries to ruin magic while enhancing skills outside of divinity, combat and spellcraft.…

…that is, unless he can learn to exploit the hell out of it.

There was a Senior Brother and a Junior Sister. One of them was transmigrated to this world and had cheats while the other was the reincarnation of a Great Emperor.