MTL - WARNING! Tsundere President - Chapter 2 2. Dangerous relationship (2)

A Di [legitimate-born] daughter of a noble house turns into an abandoned daughter. No father to dote on her, no mother to love her, no problem. She uses one silver needle to save a dying man. What’s so unusual about a medical injection? She roams all over the world with a scalpel in her hand. Cutting throats, cutting open abdomens, cutting open skulls to mend bones. With amazing medical skills and ethics, she gathers a flock of officials, obtains the will of heavens, gains public favor, and receives Taizi’s [Crown Prince] doting. In the midst of a powerful momentum, her cheap father comes to reunite. She coldly refuses to go home or acknowledge ancestors.

“I was abandoned by you over and over again. Now you want to use familial affection to coax me back. You don’t want to recognize this daughter. My heart is cold, I want to leave. Beat it, father!”

- Description from Novelupdates

In the rebirth, in order to prevent the tragedy of the previous life from happening, Bai Yu decided to rush to the [Tower of God] at any cost, and face everything together with his sister!

However, Bai Yu, who was bound by the system, mutated his bloodline, and transformed into a black-scaled python seems to be developing on a completely different path from his previous life…

- Description from novelbuddy

This is an alternate history. Decades after the fall of the Eastern Jin Dynasty, the world is still in chaos, although there is hope for reunification.